Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982677 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTNPC1RAB9ADHFR | |
| SCHEMBL7969549 | 0.77 | KDM4E (0.51) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7982628 | 0.75 | TDP1 (0.39) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL9226257 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTNPC1RAB9ADHFR | |
| SCHEMBL7969399 | 0.74 | ALDH1A1 (0.50) | SMN1; SMN2MAPTNPC1RAB9ANPSR1 | |
| SCHEMBL7982689 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2MAPTNPC1RAB9ADHFR | |
| SCHEMBL2489626 | 0.71 | RAB9A (0.49) | SMN1; SMN2MAPTNPC1RAB9ADHFR | |
| SCHEMBL7980749 | 0.70 | NOS2 (0.42) | NPSR1 | |
| SCHEMBL7980201 | 0.70 | RAB9A (0.38) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL7969572 | 0.68 | HRH4 (0.42) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |