Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983648 | 0.95 | LCK (0.57) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7980015 | 0.93 | LCK (0.52) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983613 | 0.88 | LCK (0.51) | LCKFGFR1SRCALDH1A1HSD17B10 | |
| SCHEMBL7983672 | 0.85 | FGFR1 (0.53) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983879 | 0.85 | FGFR1 (0.55) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7984551 | 0.83 | FGFR1 (0.48) | LCKFGFR1SRCALDH1A1KDM4E | |
| SCHEMBL4041225 | 0.83 | FGFR1 (0.51) | LCKFGFR1SRCKDRALDH1A1 | |
| SCHEMBL7983062 | 0.82 | LCK (0.50) | LCKFGFR1KDRPDE2A | |
| SCHEMBL7979955 | 0.81 | LCK (0.54) | LCKFGFR1KDRPDE2A | |
| SCHEMBL7980189 | 0.81 | CAMK2D (0.44) | LCKFGFR1KDRRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |