Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | IL6 | P05231 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | BAX | Q07812 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372017 | 0.80 | TNF (0.46) | TNFIL6MAOBCYP24A1MAPT | |
| SCHEMBL4157687 | 0.73 | TNF (0.50) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL7983283 | 0.69 | NQO2 (0.54) | — | |
| SCHEMBL7980865 | 0.69 | LCK (0.46) | BACE1MAPT | |
| SCHEMBL29446986 | 0.68 | NFKB1 (0.52) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL165004 | 0.68 | NFKB1 (0.52) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL11126093 | 0.68 | NFKB1 (0.57) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL25375799 | 0.67 | TNF (0.59) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL2494559 | 0.67 | NFKB1 (0.55) | NFKB1TNFIL6GRIN2DGRIN3B | |
| SCHEMBL323188 | 0.65 | NFKB1 (0.53) | NFKB1TNFIL6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |