Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | IL6 | P05231 | 2/20 | 0.46 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983285 | 0.80 | NFKB1 (0.44) | TNFIL6CYP24A1MAOBMAPT | |
| SCHEMBL9372014 | 0.72 | NFE2L2 (0.44) | MAPTLMNANFE2L2MEN1KMT2A | |
| SCHEMBL7980263 | 0.72 | CYP1A1 (0.50) | MAPTLMNASMN1; SMN2NFE2L2TRPA1 | |
| SCHEMBL4157687 | 0.70 | TNF (0.50) | TNFIL6CYP24A1MAPTLMNA | |
| SCHEMBL14674464 | 0.69 | MDM2 (0.58) | CYP24A1MAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL28031997 | 0.69 | TNF (0.69) | TNFIL6CYP24A1MAOBMAPT | |
| SCHEMBL28031993 | 0.69 | TNF (0.69) | TNFIL6CYP24A1MAOBMAPT | |
| SCHEMBL30093322 | 0.68 | CA1 (0.55) | MAOBLMNAATMNFE2L2TRPA1 | |
| SCHEMBL255270 | 0.68 | CA1 (0.55) | MAOBLMNAATMNFE2L2TRPA1 | |
| SCHEMBL12486515 | 0.68 | PTGER4 (0.51) | MAOBMAPTLMNAGAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |