Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | STS | P08842 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971782 | 0.89 | SIGMAR1 (0.69) | SIGMAR1 | |
| SCHEMBL8526553 | 0.86 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1BLMKDM4E | |
| SCHEMBL7989733 | 0.85 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL13913655 | 0.83 | KDM4E (0.60) | GPR119STSJAK2JAK1KDM4E | |
| SCHEMBL3358948 | 0.82 | KDM4E (0.59) | GPR119ALDH1A1STSJAK2JAK1 | |
| SCHEMBL3712707 | 0.81 | MEN1 (0.59) | SIGMAR1STSPOLBKCNH2 | |
| SCHEMBL13954406 | 0.81 | GPR119 (0.67) | GPR119STSJAK2JAK1KDM4E | |
| SCHEMBL27648293 | 0.81 | MAPT (0.56) | GPR119SIGMAR1ALDH1A1STSJAK2 | |
| SCHEMBL1912705 | 0.80 | KDM4E (0.62) | GPR119STSJAK2JAK1KDM4E | |
| SCHEMBL4213070 | 0.79 | DRD4 (0.57) | GPR119SIGMAR1ALDH1A1STSJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |