Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994150 | 0.81 | KMT2A (0.42) | KMT2ALMNAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6968314 | 0.79 | LMNA (0.45) | KMT2ALMNAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4039966 | 0.79 | LMNA (0.41) | KMT2ALMNAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15881082 | 0.77 | ALDH1A1 (0.41) | KMT2ALMNAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL321951 | 0.75 | — | — | |
| SCHEMBL29862129 | 0.75 | — | — | |
| SCHEMBL2547519 | 0.75 | LMNA (0.51) | KMT2ALMNAMEN1SMN1; SMN2MAPT | |
| SCHEMBL9326030 | 0.73 | L3MBTL1 (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8459579 | 0.73 | PTK2 (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7963225 | 0.71 | CA12 (0.38) | KMT2AMEN1ALDH1A1MAPTNNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| WO-2001007416-A1 | METHOD OF PRODUCING PYRIDAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 2001-02-01 | — | — | WO | disclosed |