Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11113084 | 0.87 | MKNK1 (0.48) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| SCHEMBL27379515 | 0.81 | PTK2 (0.49) | PTK2L3MBTL1MEN1KMT2ALIPE | |
| SCHEMBL3363976 | 0.81 | PTK2 (0.46) | PTK2L3MBTL1MEN1KMT2ALIPE | |
| SCHEMBL8096967 | 0.80 | ACACB (0.42) | MEN1KMT2A | |
| SCHEMBL9155382 | 0.80 | MAPK1 (0.40) | PTK2L3MBTL1MEN1KMT2ALIPE | |
| SCHEMBL4634081 | 0.79 | L3MBTL1 (0.44) | PTK2L3MBTL1LIPETDP1RAB9A | |
| SCHEMBL4634579 | 0.79 | LIPE (0.47) | PTK2L3MBTL1MEN1KMT2ALIPE | |
| SCHEMBL9018039 | 0.79 | KDM4E (0.44) | MEN1KMT2APABPC1RAB9AHTT | |
| SCHEMBL3985855 | 0.79 | KDM4E (0.46) | RAB9AMAPK1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL7862661 | 0.78 | KDM4E (0.39) | MEN1KMT2ARAB9AMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582825-B1 | Amidation of pyridines | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| EP-0582825-A1 | Amidation of pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-02-16 | — | — | EP | disclosed |
| EP-0385210-A2 | Amidation of pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-05 | — | — | EP | disclosed |