SCHEMBL7983386

SCHEMBL7983386

CC1(c2ccccc2)OC(=O)CC1(O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
CYP1A2 P05177 3/20 0.39
HCAR3 P49019 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
EGFR P00533 1/20 0.38
POLB P06746 1/20 0.38
GPR55 Q9Y2T6 1/20 0.38
CFTR P13569 1/20 0.37
GOPC Q9HD26 1/20 0.37
HSD11B1 P28845 1/20 0.36
GAA P10253 2/20 0.36
LDHA P00338 1/20 0.36
KDM4E B2RXH2 1/20 0.36
SIRT1 Q96EB6 1/20 0.36
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
BACE1 P56817 1/20 0.35
CHRNB2 P17787 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5183115 0.75 ALDH1A1 (0.44) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9
SCHEMBL4258794 0.70 CFTR (0.45) ALDH1A1HCAR3HCAR2CYP2C9CYP2C19
SCHEMBL5857767 0.67 MMP2 (0.41) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9
SCHEMBL7863381 0.66 HCAR3 (0.40) ALDH1A1CYP1A2HCAR3HCAR2EGFR
SCHEMBL3291202 0.66 SIRT1 (0.46) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9
SCHEMBL6856757 0.66 ALDH1A1 (0.44) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9
SCHEMBL29223627 0.66 HCAR3 (0.40) ALDH1A1CYP1A2HCAR3HCAR2EGFR
SCHEMBL4226505 0.66 ALDH1A1 (0.43) ALDH1A1CYP1A2HCAR3HCAR2POLB
SCHEMBL15116234 0.64 MMP2 (0.38) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9
SCHEMBL11312627 0.64 MMP2 (0.42) ALDH1A1CYP1A2HCAR3HCAR2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6262073-B1 INHIBITING THE ACTION OF A PRO-INFLAMMATORY CYTOKINE OXIS INTERNATIONAL INC. 2001-07-17 US disclosed