Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 4/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977146 | 0.86 | TP53 (0.38) | EGFRIGF1RFLT4KDR | |
| SCHEMBL7980657 | 0.86 | HTR1D (0.35) | EGFRIGF1RFLT4KDRHTR1B | |
| SCHEMBL7983973 | 0.84 | HTR1B (0.49) | EGFRIGF1RFLT4KDRHTR1B | |
| SCHEMBL6905932 | 0.79 | CTSV (0.41) | — | |
| SCHEMBL7983967 | 0.76 | HTR1D (0.48) | EGFRIGF1RFLT4KDRHTR1B | |
| SCHEMBL7072937 | 0.76 | KIF11 (0.36) | EGFRIGF1RHTR1BHTR1D | |
| SCHEMBL7980782 | 0.73 | MAPT (0.38) | — | |
| SCHEMBL7983732 | 0.72 | TP53 (0.39) | — | |
| SCHEMBL7980659 | 0.71 | HTR1D (0.36) | HTR1BHTR1D | |
| SCHEMBL21900694 | 0.70 | HTR1B (0.81) | EGFRIGF1RFLT4KDRHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |