Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR1B | P28222 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980659 | 0.86 | HTR1D (0.36) | HTR1DHTR1BHTR1AKIT | |
| SCHEMBL7983970 | 0.86 | EGFR (0.49) | HTR1DHTR1BEGFRIGF1RFLT4 | |
| SCHEMBL7977146 | 0.81 | TP53 (0.38) | EGFRIGF1RFLT4KDR | |
| SCHEMBL7980655 | 0.79 | ADRB3 (0.44) | — | |
| SCHEMBL11418263 | 0.79 | MCHR1 (0.49) | — | |
| SCHEMBL7977557 | 0.78 | L3MBTL1 (0.47) | KIT | |
| SCHEMBL7111545 | 0.76 | MTNR1A (0.57) | HTR1DHTR1BHTR1AMTNR1AMTNR1B | |
| SCHEMBL7070543 | 0.74 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| SCHEMBL6905932 | 0.74 | CTSV (0.41) | — | |
| SCHEMBL11282223 | 0.74 | HTR1D (0.45) | HTR1DHTR1BMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |