Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | MMP16 | P51512 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987031 | 0.87 | NOX4 (0.54) | NOX4TP53GAAHTR6RXFP1 | |
| SCHEMBL7983968 | 0.85 | SRC (0.56) | TP53GAASRCPOLBSMN1; SMN2 | |
| SCHEMBL7970469 | 0.83 | NOX4 (0.71) | NOX4TP53GAAHTR6RXFP1 | |
| SCHEMBL7970968 | 0.79 | TSHR (0.47) | TP53SRCSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7970608 | 0.74 | SRC (0.50) | TP53GAAHTR6SRCALDH1A1 | |
| SCHEMBL7987332 | 0.73 | SRC (0.72) | NOX4PTGDR2SRC | |
| SCHEMBL7987028 | 0.73 | SRC (0.57) | TP53SRCPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7983938 | 0.71 | SRC (0.50) | TP53GAARXFP1SRCSMN1; SMN2 | |
| SCHEMBL7984408 | 0.70 | SRC (0.51) | GAASRCALDH1A1MAPT | |
| SCHEMBL7981648 | 0.70 | SRC (0.53) | TP53RXFP1SRCSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |