Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | PRKACG | P22612 | 1/20 | 0.49 |
| ▸ | PRKACB | P22694 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987031 | 0.87 | NOX4 (0.54) | NOX4SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7970466 | 0.84 | SRC (0.69) | NOX4SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7983976 | 0.83 | NOX4 (0.49) | NOX4SRCHTR6TP53GAA | |
| SCHEMBL7981060 | 0.83 | NOX4 (1.00) | NOX4SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7970086 | 0.78 | SRC (0.63) | SRCPRKACAPRKACGPRKACBTP53 | |
| SCHEMBL7980611 | 0.72 | SRC (0.60) | SRCTSHRMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7987028 | 0.72 | SRC (0.57) | SRCPRKACAPRKACGPRKACBTP53 | |
| SCHEMBL7981611 | 0.71 | NOX4 (0.77) | NOX4SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7984333 | 0.69 | MAPT (0.53) | SRCTP53TSHRMAPTALDH1A1 | |
| SCHEMBL9254895 | 0.68 | HTR6 (0.56) | NOX4HTR6GAAMMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |