Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985473 | 0.91 | HPGD (0.49) | HPGDPAX8ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7988789 | 0.90 | BRD4 (0.40) | HPGDABCC8KCNJ11PAX8ALDH1A1 | |
| SCHEMBL7984731 | 0.86 | ABCC8 (0.39) | ABCC8KCNJ11PAX8NR1H4GNRHR | |
| SCHEMBL7984728 | 0.83 | NR1H4 (0.41) | ABCC8KCNJ11PAX8ALDH1A1NR1H4 | |
| SCHEMBL7974152 | 0.82 | HPGD (0.47) | HPGDPAX8ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7988517 | 0.82 | ABCC8 (0.47) | HPGDABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7987359 | 0.81 | TNKS (0.48) | HPGDABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7992290 | 0.81 | HPGD (0.42) | HPGDABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7974486 | 0.81 | SMN1; SMN2 (0.50) | HPGDABCC8KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL7984930 | 0.80 | ABCC8 (0.47) | HPGDABCC8KCNJ11ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |