Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PARN | O95453 | 1/20 | 0.36 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984727 | 0.91 | HPGD (0.40) | HPGDSMN1; SMN2ALDH1A1KMT2APAX8 | |
| SCHEMBL7974152 | 0.91 | HPGD (0.47) | HPGDSMN1; SMN2ALDH1A1KMT2APAX8 | |
| SCHEMBL7985482 | 0.86 | PAX8 (0.43) | HPGDSMN1; SMN2ALDH1A1PAX8ADORA2B | |
| SCHEMBL7988789 | 0.83 | BRD4 (0.40) | HPGDSMN1; SMN2ALDH1A1KMT2APAX8 | |
| SCHEMBL7984479 | 0.83 | HPGD (0.52) | HPGDSMN1; SMN2ALDH1A1KMT2APRMT5 | |
| SCHEMBL7985478 | 0.82 | PAX8 (0.45) | HPGDSMN1; SMN2ALDH1A1PAX8MCL1 | |
| SCHEMBL7985463 | 0.80 | HPGD (0.52) | HPGDSMN1; SMN2ALDH1A1KMT2AMCL1 | |
| SCHEMBL7975265 | 0.80 | SMN1; SMN2 (0.61) | HPGDSMN1; SMN2ALDH1A1KMT2AADORA2B | |
| SCHEMBL7974033 | 0.79 | HPGD (0.49) | HPGDSMN1; SMN2ALDH1A1KMT2AMCL1 | |
| SCHEMBL7988556 | 0.79 | SMN1; SMN2 (0.58) | HPGDSMN1; SMN2ALDH1A1KMT2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |