Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994925 | 0.88 | PTGES (0.40) | PTGESHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7994951 | 0.82 | PTGES (0.56) | PTGESHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7984773 | 0.72 | PTGES (0.41) | PTGESMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL7994861 | 0.70 | PTGES (0.59) | PTGESALDH1A1POLBMEN1KMT2A | |
| SCHEMBL22535966 | 0.64 | HPGD (0.47) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL7996571 | 0.62 | USP8 (0.59) | PTGESHPGDKDM4EALDH1A1POLB | |
| SCHEMBL18703867 | 0.60 | ALDH1A1 (0.43) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL22656552 | 0.59 | POLB (0.50) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL24908732 | 0.59 | KDM4E (0.47) | HPGDKDM4EALDH1A1HSD17B10POLB | |
| SCHEMBL20398155 | 0.59 | DDB1 (0.49) | HPGDKDM4EALDH1A1HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |