Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 3/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984591 | 0.88 | PTGES (0.61) | PTGESTDP2TTRPOLBALDH1A1 | |
| SCHEMBL7994951 | 0.88 | PTGES (0.56) | PTGESDDB1CRBNTDP2PTPN1 | |
| SCHEMBL7996719 | 0.81 | PTGES (0.64) | PTGESCTNNB1ALDH1A1MAPTMEN1 | |
| SCHEMBL7994925 | 0.81 | PTGES (0.40) | PTGESPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7984832 | 0.78 | PTGES (0.63) | PTGESMAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL7996575 | 0.76 | PTGES (0.55) | PTGESTTRMAPTMEN1KMT2A | |
| SCHEMBL7995005 | 0.76 | PTGES (0.57) | PTGESPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7996440 | 0.75 | PTGES (0.54) | PTGESPOLBALDH1A1MAPTL3MBTL1 | |
| SCHEMBL7994971 | 0.75 | PTGES (0.59) | PTGES | |
| SCHEMBL7984763 | 0.75 | PTGES (0.54) | PTGESPOLBALDH1A1MAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | claimed |
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |