Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.49 |
| ▸ | LIPC | P11150 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.44 |
| ▸ | PTPRC | P08575 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.41 |
| ▸ | PTPRB | P23467 | 2/20 | 0.41 |
| ▸ | PTPRE | P23469 | 2/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ASPH | Q12797 | 2/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.40 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.40 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28404418 | 0.77 | LIPC (0.47) | KDM4CLIPCLIPGKDM4EASPH | |
| SCHEMBL7991868 | 0.77 | PTPN1 (0.46) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7985611 | 0.77 | PTPN1 (0.52) | KDM4CPTPN1KDM4EASPHKDM8 | |
| SCHEMBL7985665 | 0.75 | PTPN1 (0.43) | KDM4CPTPN1PTPRCPTPN2PTPRB | |
| SCHEMBL7985103 | 0.73 | PTGS1 (0.45) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL28612582 | 0.72 | CREBBP (0.71) | — | |
| SCHEMBL7988968 | 0.72 | LMNA (0.47) | KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL194971 | 0.70 | KDM4C (0.63) | KDM4CLIPCLIPGKDM4EASPH | |
| SCHEMBL17371276 | 0.70 | KMT2A (0.49) | KDM4CLIPCLIPGNPC1RAB9A | |
| SCHEMBL7848210 | 0.70 | GPR35 (0.58) | PTPN1PTPRCPTPN2PTPRBPTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |