Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.39 |
| ▸ | PTPRC | P08575 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPRB | P23467 | 2/20 | 0.39 |
| ▸ | PTPRE | P23469 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.39 |
| ▸ | PTPRA | P18433 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991868 | 0.84 | PTPN1 (0.46) | PTGS1PTGS2PTPN1GRIK1PTPRC | |
| SCHEMBL7988976 | 0.74 | GPR35 (0.42) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7984956 | 0.73 | KDM4C (0.49) | PTPN1GRIK1PTPRCPTPN2PTPRB | |
| SCHEMBL7985843 | 0.71 | ALOX15 (0.47) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7848210 | 0.67 | GPR35 (0.58) | PTPN1GRIK1PTPRCPTPN2PTPRB | |
| SCHEMBL11035209 | 0.67 | AKR1C3 (0.49) | PTGS1PTGS2GFERHSD17B10 | |
| SCHEMBL7985749 | 0.67 | ABCC1 (0.43) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7988974 | 0.67 | PTPN1 (0.41) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| 2-(Phenylamino)Cyclohexanol SCHEMBL432136 | 0.66 | ALDH1A1 (0.51) | PTGS1PTGS2GFERGAA | |
| 2-(Phenylamino)Cyclohexanol SCHEMBL432132 | 0.66 | ALDH1A1 (0.51) | PTGS1PTGS2GFERGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |