Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974555 | 0.90 | HDAC1 (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7984257 | 0.89 | RAB9A (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1NAMPT | |
| SCHEMBL7992620 | 0.85 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7991586 | 0.83 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7984455 | 0.83 | ABCB1 (0.54) | NPC1SMN1; SMN2ALDH1A1TDP1KDM4E | |
| SCHEMBL7985361 | 0.82 | P2RY14 (0.52) | ALDH1A1KDM4E | |
| SCHEMBL7988677 | 0.81 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7974172 | 0.81 | HDAC3 (0.44) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7975241 | 0.80 | GAA (0.50) | NPC1RAB9ASMN1; SMN2GAATSHR | |
| SCHEMBL7985033 | 0.79 | NLRP3 (0.46) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |