Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991597 | 0.90 | PDE4B (0.39) | HDAC6HDAC1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL7984423 | 0.90 | SMN1; SMN2 (0.38) | HDAC6HDAC1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL7974247 | 0.90 | CYP11B1 (0.44) | HSD17B13LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL7985336 | 0.90 | PIK3CA (0.42) | HDAC6HDAC1HSD17B13SMN1; SMN2CYP11B1 | |
| SCHEMBL7974469 | 0.89 | HDAC1 (0.40) | HDAC6HDAC1LMNASMN1; SMN2CYP11B1 | |
| SCHEMBL7985613 | 0.89 | MET (0.46) | HDAC6HDAC1HSD17B13CYP11B1CYP11B2 | |
| SCHEMBL7984717 | 0.89 | SMN1; SMN2 (0.46) | HDAC6LMNASMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL7974277 | 0.88 | NR1H4 (0.44) | HDAC6HDAC1HSD17B13ADORA3ADORA1 | |
| SCHEMBL7991543 | 0.87 | GAA (0.47) | HDAC6HDAC1SMN1; SMN2ADORA1ADORA2A | |
| SCHEMBL7991646 | 0.86 | SMN1; SMN2 (0.43) | HDAC6HDAC1HSD17B13SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |