Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985010 | 0.91 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7991400 | 0.91 | NR1H4 (0.43) | NR1H4ABCC8KCNJ11HSP90AA1HSP90AB1 | |
| SCHEMBL7992267 | 0.90 | ICMT (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7974490 | 0.89 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11ADORA3 | |
| SCHEMBL7988016 | 0.89 | HDAC1 (0.44) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7985565 | 0.88 | HDAC6 (0.40) | HDAC1HDAC6HSD17B13ADORA3ADORA1 | |
| SCHEMBL7985597 | 0.88 | SERPINE1 (0.46) | NR1H4ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7984471 | 0.88 | NR1H4 (0.41) | NR1H4ABCC8KCNJ11NLRP3SERPINE1 | |
| SCHEMBL7985336 | 0.87 | PIK3CA (0.42) | HDAC1HDAC6HSD17B13ADORA3ADORA1 | |
| SCHEMBL7985613 | 0.86 | MET (0.46) | HDAC1HDAC6HSD17B13ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |