SCHEMBL7974469

SCHEMBL7974469

Cc1ccc(Cn2cnc3nc(-c4cccc(F)c4)nc(O)c32)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CYP11B1 P15538 4/20 0.39
CYP11B2 P19099 3/20 0.39
LMNA P02545 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
MET P08581 1/20 0.38
HTT P42858 1/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ACP1 P24666 1/20 0.36
GRM5 P41594 1/20 0.36
KDM4E B2RXH2 1/20 0.35
DPP4 P27487 1/20 0.35
CSNK1D P48730 1/20 0.35
WNT3A P56704 1/20 0.35
HPGDS O60760 1/20 0.34
NPC1 O15118 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7988734 0.92 MET (0.44) HDAC1HDAC6CYP11B1CYP11B2LMNA
SCHEMBL7988958 0.91 ALDH1A1 (0.42) CYP11B1CYP11B2LMNASMN1; SMN2MET
SCHEMBL7987253 0.90 HPGDS (0.40) HDAC1HDAC6CYP11B1CYP11B2SMN1; SMN2
SCHEMBL7985565 0.89 HDAC6 (0.40) HDAC1HDAC6CYP11B1CYP11B2LMNA
SCHEMBL7991669 0.89 HDAC1 (0.38) HDAC1HDAC6CYP11B1CYP11B2ACP1
SCHEMBL7992267 0.89 ICMT (0.44) HDAC1HDAC6CYP11B1CYP11B2MET
SCHEMBL7984423 0.88 SMN1; SMN2 (0.38) HDAC1HDAC6CYP11B1CYP11B2LMNA
SCHEMBL7991597 0.88 PDE4B (0.39) HDAC1HDAC6CYP11B1CYP11B2LMNA
SCHEMBL7985165 0.87 MET (0.47) HDAC1HDAC6CYP11B1CYP11B2LMNA
SCHEMBL7984717 0.87 SMN1; SMN2 (0.46) HDAC6CYP11B1CYP11B2LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6310070-B1 FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS JAPAN ENERGY CORPORATION (JP) 2001-10-30 US disclosed
EP-0999211-A1 NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF JAPAN ENERGY CORPORATION (JP) 2000-05-10 EP disclosed