SCHEMBL7985940

SCHEMBL7985940

CC1=NN(c2ccc3[nH]ncc3c2)C(=O)C(=O)C1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.44
TDO2 P48775 1/20 0.44
ROCK2 O75116 7/20 0.42
ROCK1 Q13464 4/20 0.42
RIPK2 O43353 1/20 0.41
CYP3A4 P08684 2/20 0.41
JAK2 O60674 3/20 0.41
GSK3B P49841 3/20 0.41
PIM1 P11309 2/20 0.41
CHEK1 O14757 1/20 0.41
AURKA O14965 1/20 0.41
DAPK3 O43293 1/20 0.41
PRKD3 O94806 1/20 0.41
MAP4K4 O95819 1/20 0.41
PAK4 O96013 1/20 0.41
NTRK1 P04629 1/20 0.41
FYN P06241 1/20 0.41
CSF1R P07333 1/20 0.41
RET P07949 1/20 0.41
MET P08581 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7991950 0.76 ALDH1A1 (0.33) KDM4EMEN1ALDH1A1GAAMAPT
SCHEMBL12680064 0.69 MAPKAPK2 (0.52) IDO1TDO2ROCK2ROCK1RIPK2
SCHEMBL7974687 0.69 ROCK2 (0.47) ROCK2ROCK1RIPK2CYP3A4JAK2
SCHEMBL7989367 0.68 PTGS2 (0.43) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL6736416 0.67 KMT2A (0.49) CYP3A4CYP2D6KDM4EMEN1ALDH1A1
SCHEMBL4383142 0.67 MAT2A (0.45) IDO1TDO2ROCK2ROCK1RIPK2
SCHEMBL4462803 0.66 ROCK2 (0.46) ROCK2ROCK1JAK2GSK3BPIM1
SCHEMBL26684225 0.66 MAPKAPK2 (0.54) IDO1TDO2ROCK2ROCK1CYP3A4
SCHEMBL4566556 0.66 MAPKAPK2 (0.51) IDO1TDO2ROCK2ROCK1CYP3A4
SCHEMBL12060144 0.65 GSK3B (0.50) IDO1TDO2ROCK2ROCK1JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6271373-B1 PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID VIROPHARMA INCORPORATED 2001-08-07 US disclosed
US-6180628-B1 PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES VIROPHARMA INCORPORATED 2001-01-30 US disclosed
EP-0920419-A4 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA VIROPHARMA INC (US) 1999-10-06 EP disclosed
US-5935957-A PYRIDAZINE DERIVATIVES VIROPHARMA INCORPORATED (US) 1999-08-10 US disclosed
EP-0920419-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA Viropharma Incorporated (US) 1999-06-09 EP disclosed
US-5821243-A 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC VIROPHARMA INCORPORATED (US) 1998-10-13 US disclosed
WO-1998003487-A1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA VIROPHARMA INCORPORATED (US) 1998-01-29 WO disclosed