Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985940 | 0.76 | IDO1 (0.44) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL7985908 | 0.70 | MAPT (0.35) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL7989137 | 0.69 | POLB (0.41) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL23348987 | 0.69 | POLB (0.44) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL9717736 | 0.68 | L3MBTL1 (0.40) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL23348985 | 0.68 | CA12 (0.39) | KDM4EGAA | |
| SCHEMBL7989367 | 0.68 | PTGS2 (0.43) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL6736416 | 0.67 | KMT2A (0.49) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL29367601 | 0.65 | CYP1A2 (0.39) | ALDH1A1GAAKMT2A | |
| SCHEMBL103309 | 0.65 | CYP1A2 (0.39) | ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | disclosed |
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| EP-0920419-A4 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INC (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0920419-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | Viropharma Incorporated (US) | 1999-06-09 | — | — | EP | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |
| WO-1998003487-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INCORPORATED (US) | 1998-01-29 | — | — | WO | disclosed |