Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999726 | 0.91 | FNTA (0.43) | HCRTR1HCRTR2FNTAFNTBLMNA | |
| SCHEMBL7996149 | 0.88 | HCRTR1 (0.46) | HCRTR1HCRTR2METLMNATP53 | |
| SCHEMBL8000009 | 0.83 | LMNA (0.44) | HCRTR1HCRTR2METLMNATP53 | |
| SCHEMBL7999738 | 0.82 | F10 (0.47) | HCRTR1HCRTR2LMNATP53MAPT | |
| SCHEMBL8000074 | 0.82 | LMNA (0.42) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7996031 | 0.81 | HCRTR1 (0.47) | HCRTR1HCRTR2LMNATP53MAPT | |
| SCHEMBL7986759 | 0.80 | MAPT (0.42) | HCRTR1HCRTR2LMNATP53MAPT | |
| SCHEMBL7996147 | 0.79 | LMNA (0.42) | LMNATP53MAPTTHRBF10 | |
| SCHEMBL7997639 | 0.79 | L3MBTL1 (0.45) | LMNATP53MAPTF10L3MBTL1 | |
| SCHEMBL7996072 | 0.78 | LMNA (0.46) | LMNATP53MAPTF10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |