Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986754 | 0.93 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DATM | |
| SCHEMBL7991417 | 0.92 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DATM | |
| SCHEMBL7988749 | 0.90 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7984681 | 0.90 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7985118 | 0.89 | ADRB2 (0.41) | PDE4APDE4BPDE4CPDE4DATM | |
| SCHEMBL7985410 | 0.89 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7974200 | 0.88 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7973917 | 0.88 | LMNA (0.40) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7974082 | 0.85 | L3MBTL1 (0.45) | ATMLMNAPOLBALDH1A1NPC1 | |
| SCHEMBL7984788 | 0.85 | CYP11B1 (0.45) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |