Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988749 | 0.89 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHSD17B13 | |
| SCHEMBL7984681 | 0.89 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHSD17B13 | |
| SCHEMBL7985410 | 0.88 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHSD17B13 | |
| SCHEMBL7987222 | 0.88 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7974012 | 0.86 | ALDH1A1 (0.41) | KDM4EALDH1A1KMT2AACP1ADORA3 | |
| SCHEMBL7988781 | 0.85 | MET (0.43) | PDE4BHSD17B13LMNAXPO1ACP1 | |
| SCHEMBL7988408 | 0.85 | ALDH1A1 (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7973626 | 0.84 | SMN1; SMN2 (0.45) | KDM4EACP1ADORA1HDAC1HDAC6 | |
| SCHEMBL7986754 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7985360 | 0.83 | POLB (0.40) | HSD17B13LMNAPOLBACP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |