Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PARN | O95453 | 1/20 | 0.40 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 3/20 | 0.39 |
| ▸ | PDE1A | P54750 | 3/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986760 | 0.93 | ALDH1A1 (0.41) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7991418 | 0.92 | ALDH1A1 (0.40) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7988753 | 0.90 | ACP1 (0.41) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7985415 | 0.89 | ALDH1A1 (0.39) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7985119 | 0.89 | CNOT7 (0.42) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7974203 | 0.88 | ACP1 (0.41) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7984682 | 0.88 | PDE4A (0.39) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7973921 | 0.88 | ALDH1A1 (0.42) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7984791 | 0.86 | SMN1; SMN2 (0.45) | LMNAALDH1A1PARNCNOT7MEN1 | |
| SCHEMBL7974083 | 0.86 | ACP1 (0.43) | LMNAALDH1A1PARNCNOT7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |