Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PARN | O95453 | 1/20 | 0.40 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974083 | 0.86 | ACP1 (0.43) | SMN1; SMN2ALDH1A1PARNCNOT7CYP2C9 | |
| SCHEMBL7987224 | 0.86 | LMNA (0.44) | ALDH1A1PARNCNOT7P2RX7LMNA | |
| SCHEMBL7975271 | 0.84 | CNOT7 (0.56) | SMN1; SMN2ALDH1A1PARNCNOT7KMT2A | |
| SCHEMBL7984720 | 0.84 | CNOT7 (0.48) | SMN1; SMN2CYP11B1CYP11B2ALDH1A1PARN | |
| SCHEMBL7988495 | 0.83 | ADORA2B (0.46) | SMN1; SMN2ALDH1A1PARNCNOT7TSHR | |
| SCHEMBL7988887 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP11B1CYP11B2ALDH1A1THRB | |
| SCHEMBL7984786 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP11B1CYP11B2ALDH1A1THRB | |
| SCHEMBL7974270 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2CYP11B1CYP11B2ALDH1A1PARN | |
| SCHEMBL7985002 | 0.81 | ADORA2B (0.48) | ALDH1A1CNOT7CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7985428 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1PARNCNOT7TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |