Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PARN | O95453 | 1/20 | 0.36 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988753 | 0.90 | ACP1 (0.41) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7985415 | 0.89 | ALDH1A1 (0.39) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7987224 | 0.88 | LMNA (0.44) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7974203 | 0.88 | ACP1 (0.41) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7985342 | 0.85 | CNOT7 (0.51) | ALDH1A1PTPN1PARNCNOT7 | |
| SCHEMBL7988416 | 0.85 | ALDH1A1 (0.49) | ALDH1A1P2RX7 | |
| SCHEMBL7985619 | 0.85 | CNOT7 (0.41) | HSD17B13ALDH1A1LMNAMAPK14PARN | |
| SCHEMBL7986760 | 0.84 | ALDH1A1 (0.41) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7984677 | 0.84 | TP53 (0.41) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7991638 | 0.84 | GRIN1 (0.42) | HSD17B13PARNCNOT7MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |