Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | NQO2 | P16083 | 2/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980865 | 0.83 | LCK (0.46) | LCKMEN1HPGDKMT2ATOP1 | |
| SCHEMBL7983927 | 0.82 | LCK (0.41) | LCKNQO2METAP1CSNK2A2CSNK2B | |
| SCHEMBL7983283 | 0.79 | NQO2 (0.54) | NQO2CYP1A2PIM1PTGS1PTGS2 | |
| SCHEMBL24734966 | 0.71 | PLK1 (0.44) | CSNK2A2CSNK2BCSNK2A1CSNK2A3PLK1 | |
| SCHEMBL6239187 | 0.68 | MIF (0.64) | PLK1FLT3RETPLK4PDGFRB | |
| SCHEMBL20299553 | 0.67 | LCK (0.66) | LCKMETAP1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17199708 | 0.67 | S100A4 (0.48) | LCKPLK4MEN1KMT2AMAOB | |
| SCHEMBL18068471 | 0.66 | BCL2 (0.45) | LCKALDH1A1KDM4EHPGDAPEX1 | |
| SCHEMBL10595101 | 0.64 | ALOX5 (0.56) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL20873238 | 0.64 | ALOX5 (0.56) | ALDH1A1KDM4EMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |