Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.55 |
| ▸ | MMP12 | P39900 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.46 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205026 | 0.78 | ALDH1A1 (0.58) | KEAP1ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL6340411 | 0.78 | MMP12 (0.59) | KEAP1MMP12MMP13HDAC1ALDH1A1 | |
| SCHEMBL27540333 | 0.78 | PKM (0.62) | KEAP1MMP12MMP13HDAC1ALDH1A1 | |
| SCHEMBL29928918 | 0.76 | PKM (0.58) | MMP12MMP13HDAC1ALDH1A1HTT | |
| SCHEMBL20846871 | 0.76 | PKM (0.58) | MMP12MMP13HDAC1ALDH1A1HTT | |
| SCHEMBL7866143 | 0.75 | LMNA (0.59) | KEAP1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16397682 | 0.74 | BCL2 (0.55) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL15896281 | 0.74 | MMP12 (0.60) | KEAP1MMP12MMP13HDAC1ALDH1A1 | |
| SCHEMBL6342584 | 0.73 | MMP12 (0.66) | KEAP1MMP12MMP13HDAC1ALDH1A1 | |
| SCHEMBL28747284 | 0.73 | MMP12 (0.66) | KEAP1MMP12MMP13HDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294674-B1 | FOR THERAPY OF MULTIPLE SCLEROSIS, ATHEROSCLEROTIC PLAQUE RUPTURE, RESTENOSIS, AORTIC ANEURISM, HEART FAILURE, PERIODONTAL DISEASE, CORNEAL ULCERATION, BURNS, DECUBITAL ULCERS, CHRONIC ULCERS OR WOUNDS, CANCER METASTASIS | WARNER-LAMBERT COMPANY | 2001-09-25 | — | — | US | disclosed |