Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991565 | 0.89 | TSHR (0.49) | FGFR1FGFR4SMN1; SMN2LMNAHTT | |
| SCHEMBL7985495 | 0.88 | CYP11B1 (0.39) | FGFR1FGFR4SMN1; SMN2LMNANPSR1 | |
| SCHEMBL7988641 | 0.87 | KMT2A (0.44) | FGFR1FGFR4SMN1; SMN2LMNANPC1 | |
| SCHEMBL7984711 | 0.87 | ABCC8 (0.44) | FGFR1FGFR4NPC1RAB9ASCD | |
| SCHEMBL7986400 | 0.86 | YTHDC1 (0.47) | FGFR1FGFR4SMN1; SMN2LMNANPSR1 | |
| SCHEMBL7987961 | 0.86 | MAPT (0.47) | LMNACYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL7974324 | 0.84 | TNF (0.44) | SMN1; SMN2LMNANPC1RAB9AHTT | |
| SCHEMBL7985508 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL7987598 | 0.83 | RIOK2 (0.41) | FGFR1FGFR4SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL7974162 | 0.83 | KDM4E (0.52) | FGFR1FGFR4SMN1; SMN2HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |