Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315754 | 0.94 | FFAR1 (0.48) | MEN1KMT2AKDM4CFFAR1LMNA | |
| SCHEMBL12521895 | 0.89 | CTSK (0.46) | KMT2AFFAR1MAOBMAOAPPARG | |
| SCHEMBL8889741 | 0.87 | FFAR1 (0.48) | FFAR1GRM2MMP2MMP13MAOB | |
| SCHEMBL8181635 | 0.85 | CA2 (0.41) | MEN1KMT2AFFAR1MMP2MMP13 | |
| SCHEMBL8888011 | 0.84 | LTA4H (0.49) | FFAR1GRM2BCHEFFAR4HPGD | |
| SCHEMBL8172462 | 0.83 | MAOB (0.48) | MEN1KMT2ALMNAMAOBMAOA | |
| SCHEMBL8888854 | 0.83 | MGLL (0.50) | FFAR1GRM2BCHEFFAR4HPGD | |
| SCHEMBL8890354 | 0.83 | MGLL (0.50) | FFAR1GRM2BCHEFFAR4HPGD | |
| SCHEMBL8888505 | 0.83 | MGLL (0.50) | FFAR1GRM2BCHEFFAR4HPGD | |
| SCHEMBL8312946 | 0.81 | CYP4F2 (0.39) | MEN1KMT2AFFAR1PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |
| US-5391565-A | Hypoglycemic agents; antilipemic agents; hypotensive agents | BEECHAN GROUP P.L.C. (GB) | 1995-02-21 | — | — | US | disclosed |