Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984208 | 0.92 | MAPT (0.39) | PDE1APDE1BPDE1CBRD4NPSR1 | |
| SCHEMBL7988533 | 0.90 | TAAR1 (0.43) | BRD4CDK9HSD17B13CYP11B1CYP11B2 | |
| SCHEMBL7988660 | 0.87 | CYP11B1 (0.49) | ALDH1A1TSHRCYP11B1CYP11B2MAPT | |
| SCHEMBL7989501 | 0.87 | CDK9 (0.38) | BRD4ALDH1A1CDK9HSD17B13CYP11B1 | |
| SCHEMBL7991724 | 0.86 | SMN1; SMN2 (0.47) | BRD4MAPK1KDM4E | |
| SCHEMBL7988957 | 0.86 | MET (0.45) | NPSR1ALDH1A1TSHRCYP11B1CYP11B2 | |
| SCHEMBL7989407 | 0.86 | HPGD (0.44) | ALDH1A1PKMTSHRCYP11B1CYP11B2 | |
| SCHEMBL7984135 | 0.84 | GAA (0.49) | ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL7985861 | 0.81 | CNOT7 (0.44) | ALDH1A1PKMHSD17B13CYP11B1PPARG | |
| SCHEMBL7991669 | 0.81 | HDAC1 (0.38) | BRD4CDK9HSD17B13CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |