Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DBH | P09172 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988484 | 0.92 | PDE1A (0.43) | MAPTTHRBBRD4CYP11B1CYP11B2 | |
| SCHEMBL7989501 | 0.88 | CDK9 (0.38) | MAPTTHRBBRD4CYP11B1CYP11B2 | |
| SCHEMBL7974260 | 0.87 | CYP11B1 (0.47) | MAPTCYP11B1CYP11B2ALDH1A1TSHR | |
| SCHEMBL7988533 | 0.86 | TAAR1 (0.43) | BRD4CYP11B1CYP11B2HSD17B13EPHX2 | |
| SCHEMBL7984754 | 0.86 | SMN1; SMN2 (0.47) | BRD4CYP11B1CYP11B2MAPK1KDM4E | |
| SCHEMBL7984526 | 0.85 | MET (0.46) | CYP11B1CYP11B2ALDH1A1KDM4EHPGD | |
| SCHEMBL7975252 | 0.85 | HPGD (0.45) | CYP11B1CYP11B2ALDH1A1PKMTSHR | |
| SCHEMBL7984497 | 0.84 | MET (0.41) | CYP11B1CYP11B2ALDH1A1TSHRHPGD | |
| SCHEMBL7984512 | 0.84 | GAA (0.50) | MAPTLMNARXFP1GAA | |
| SCHEMBL7985651 | 0.82 | CYP1A2 (0.41) | ALDH1A1PKMHPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |