Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984897 | 0.94 | GAA (0.46) | GAANR1H2NR1H3ALDH1A1CYP1A2 | |
| SCHEMBL7974584 | 0.90 | GAA (0.56) | GAANR1H2NR1H3ALDH1A1MAPT | |
| SCHEMBL7985850 | 0.86 | GAA (0.49) | GAANR1H2NR1H3CLK4TP53 | |
| SCHEMBL7984406 | 0.86 | CASR (0.43) | ALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL7974615 | 0.86 | ADORA2A (0.44) | ALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL7974018 | 0.85 | GAA (0.53) | GAANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL7988583 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTHPGDLMNA | |
| SCHEMBL7988551 | 0.84 | ADORA3 (0.43) | ALDH1A1KDM4EHPGDADORA2AADORA1 | |
| SCHEMBL7984683 | 0.84 | CNOT7 (0.37) | ALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL7985378 | 0.83 | TSHR (0.47) | GAANR1H2NR1H3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |