Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4379715 | 0.93 | HTR2A (0.40) | ATML3MBTL1ALDH1A1GAAKDM4E | |
| Oxalic Acid SCHEMBL7994745 | 0.80 | GAA (0.46) | ATML3MBTL1ALDH1A1GAAKDM4E | |
| SCHEMBL7989029 | 0.74 | ATM (0.39) | ATML3MBTL1ALDH1A1GAAKDM4E | |
| SCHEMBL4386655 | 0.72 | KDM4E (0.42) | ATML3MBTL1ALDH1A1GAAKDM4E | |
| Oxalic Acid SCHEMBL7990786 | 0.71 | KDM4E (0.52) | L3MBTL1ALDH1A1GAAKDM4EPTGES | |
| Oxalic Acid SCHEMBL7990904 | 0.70 | RXFP1 (0.43) | L3MBTL1ALDH1A1GAAKDM4EMAPT | |
| SCHEMBL4386660 | 0.69 | PNMT (0.43) | HTR2AHTR2CHTR2B | |
| Oxalic Acid SCHEMBL5155135 | 0.68 | NOS2 (0.34) | — | |
| SCHEMBL7991161 | 0.68 | NPSR1 (0.43) | L3MBTL1ALDH1A1GAAKDM4EPPARG | |
| SCHEMBL23598418 | 0.68 | MLYCD (0.45) | L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |