Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16527361 | 0.83 | SMN1; SMN2 (0.62) | AKR1C3AKR1C2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30996183 | 0.81 | ABL1 (0.63) | KMT2AHDAC4HDAC2HDAC8 | |
| SCHEMBL8480988 | 0.81 | ABL1 (0.63) | KMT2AHDAC4HDAC2HDAC8 | |
| SCHEMBL8202718 | 0.79 | PRKAB2 (0.55) | AKR1C3AKR1C2SMN1; SMN2LMNAHPGD | |
| SCHEMBL7591657 | 0.77 | SMN1; SMN2 (0.75) | AKR1C3AKR1C2SMN1; SMN2HPGDPRKAB2 | |
| SCHEMBL7553675 | 0.76 | RARA (0.58) | ACLYSLC6A9MAP4K4 | |
| SCHEMBL27542071 | 0.76 | BACE1 (0.56) | SMN1; SMN2MEN1KMT2AHPGDHDAC4 | |
| SCHEMBL28694686 | 0.76 | DCLRE1B (0.56) | AKR1C2DCLRE1BACLYGRIK1MAP4K4 | |
| SCHEMBL7606419 | 0.75 | PTPN11 (0.53) | SMN1; SMN2HPGDNPC1RAB9AKDM4E | |
| SCHEMBL6701301 | 0.75 | SMN1; SMN2 (0.63) | AKR1C3AKR1C2SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258843-B1 | DRUGS AS ENZYME INHIBITORS | NOVARTIS AG (CH) | 2001-07-10 | — | — | US | disclosed |