Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | PRKX | P51817 | 2/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.45 |
| ▸ | GRK5 | P34947 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | LPO | P22079 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974018 | 0.92 | GAA (0.53) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7985850 | 0.91 | GAA (0.49) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7987433 | 0.89 | ROCK2 (0.54) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7988750 | 0.89 | GAA (0.46) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7984696 | 0.88 | GAA (0.47) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7985653 | 0.87 | GAA (0.46) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7988747 | 0.86 | CYP11B1 (0.44) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7974093 | 0.86 | GAA (0.48) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7974314 | 0.86 | GAA (0.46) | ROCK2ROCK1GAATP53RXFP1 | |
| SCHEMBL7974584 | 0.85 | GAA (0.56) | GAATP53RXFP1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |