Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL7989270 | 0.87 | PLA2G4B (0.59) | HPGDALDH1A1LMNAMAPTFKBP1A | |
| Morpholine SCHEMBL7988982 | 0.84 | RAB9A (0.46) | HPGDALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL275646 | 0.83 | PARP10 (0.66) | HPGDALDH1A1PARP10NPC1PLK1 | |
| 1,4-Diethoxybenzene SCHEMBL10980721 | 0.81 | NQO1 (0.52) | HPGDALDH1A1LMNAMAPTFKBP1A | |
| SCHEMBL6642345 | 0.78 | PARP10 (0.59) | HPGDALDH1A1PARP10NPC1PLK1 | |
| Morpholine SCHEMBL16244866 | 0.77 | FKBP1A (0.43) | HPGDALDH1A1LMNAMAPTFKBP1A | |
| SCHEMBL7721896 | 0.75 | TP53 (0.58) | HPGDALDH1A1PARP10NPC1PLK1 | |
| 1,4-Diethoxybenzene SCHEMBL6015232 | 0.75 | NQO1 (0.44) | HPGDALDH1A1LMNAMAPTFKBP1A | |
| Morpholine SCHEMBL7985369 | 0.74 | NR1H4 (0.56) | HPGDALDH1A1LMNAMAPTNPC1 | |
| Morpholine SCHEMBL27324712 | 0.72 | FKBP1A (0.41) | HPGDALDH1A1LMNAMAPTFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |