Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.67 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.56 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.56 |
| ▸ | HTR7 | P34969 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7537269 | 0.81 | MEN1 (0.52) | HTR1AMEN1KMT2ALMNABLM | |
| Fumaric Acid SCHEMBL7537262 | 0.81 | MEN1 (0.52) | HTR1AMEN1KMT2ALMNABLM | |
| SCHEMBL7474356 | 0.80 | HTR1A (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| SCHEMBL8010247 | 0.80 | HTR1A (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| SCHEMBL7474354 | 0.80 | HTR1A (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| Way-100,635 SCHEMBL30366505 | 0.79 | SMN1; SMN2 (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| Way-100,635 SCHEMBL29519870 | 0.79 | SMN1; SMN2 (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| Way-100,635 SCHEMBL4077975 | 0.79 | SMN1; SMN2 (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| Way-100,635 SCHEMBL4077972 | 0.79 | SMN1; SMN2 (1.00) | HTR1AMEN1KMT2ALMNABLM | |
| SCHEMBL7536573 | 0.79 | DRD2 (0.64) | HTR1AMEN1KMT2ADRD4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6306859-B1 | PIPERIDINE ALKYL IMIDES AS NEUROTRANSMITTERS | AMERICAN HOME PRODUCTS CORPORATION | 2001-10-23 | — | — | US | disclosed |