Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.52 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.44 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.41 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7537269 | 1.00 | MEN1 (0.52) | MEN1KMT2ALMNABLMPMP22 | |
| Fumaric Acid SCHEMBL7989873 | 0.81 | HTR1A (0.67) | MEN1KMT2ALMNABLMPMP22 | |
| Way-100,635 SCHEMBL29519870 | 0.68 | SMN1; SMN2 (1.00) | MEN1KMT2ALMNABLMPMP22 | |
| Way-100,635 SCHEMBL4077972 | 0.68 | SMN1; SMN2 (1.00) | MEN1KMT2ALMNABLMPMP22 | |
| Way-100,635 SCHEMBL4077975 | 0.68 | SMN1; SMN2 (1.00) | MEN1KMT2ALMNABLMPMP22 | |
| Way-100,635 SCHEMBL30366505 | 0.68 | SMN1; SMN2 (1.00) | MEN1KMT2ALMNABLMPMP22 | |
| SCHEMBL9413238 | 0.65 | DRD2 (0.51) | LMNAHTR1AHTR7ADRB1SLC6A2 | |
| Hydrochloric Acid SCHEMBL7536688 | 0.65 | HTR1A (0.72) | MEN1KMT2ALMNABLMPMP22 | |
| SCHEMBL6933223 | 0.64 | HTR1A (0.75) | MEN1KMT2ALMNABLMPMP22 | |
| SCHEMBL25407029 | 0.64 | DRD2 (0.64) | LMNASMN1; SMN2HTR1AHTR7ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020013324-A1 | N-substituted imide derivatives with serotonergic activity | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013324-A1 | N-substituted imide derivatives with serotonergic activity | TPH1, HTR1A, HTR1E | MEN1 389/4885KMT2A 1355/4885ADRB1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.