Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977819 | 0.99 | CHEK2 (0.51) | CHEK2NPC1RAB9ATP53MAPK1 | |
| SCHEMBL7991747 | 0.89 | PARP1 (0.53) | CHEK2ALDH1A1MAPTKDM4EMAPK13 | |
| SCHEMBL7989662 | 0.88 | LMNA (0.45) | CHEK2ALDH1A1MAPTHPGDSIRT2 | |
| SCHEMBL7989265 | 0.87 | SIRT2 (0.47) | CHEK2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL7991843 | 0.87 | AURKA (0.45) | CHEK2ALDH1A1MAPTHPGDSIRT2 | |
| SCHEMBL7978031 | 0.84 | SIRT2 (0.61) | CHEK2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL7977935 | 0.84 | CHEK2 (0.53) | CHEK2RAB9ATP53ALDH1A1MAPT | |
| SCHEMBL7987913 | 0.82 | SIRT2 (0.59) | CHEK2NPC1RAB9ATP53MAPK1 | |
| SCHEMBL7989851 | 0.82 | PARP1 (0.45) | CHEK2ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL7988176 | 0.79 | ALDH1A1 (0.44) | CHEK2NPC1RAB9ATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |