Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977819 | 0.91 | CHEK2 (0.51) | PARP1CHEK2SIRT2SIRT1ALOX5 | |
| SCHEMBL7989851 | 0.90 | PARP1 (0.45) | PARP1CHEK2PIN1CFTRAKR1C3 | |
| SCHEMBL7989895 | 0.89 | CHEK2 (0.50) | PARP1CHEK2SIRT2SIRT1ALOX5 | |
| SCHEMBL7991773 | 0.88 | PARP1 (0.51) | PARP1CHEK2PIN1AKR1C3PRKAB2 | |
| SCHEMBL7989978 | 0.84 | SIRT2 (0.61) | PARP1CHEK2SIRT2SIRT1ALOX5 | |
| SCHEMBL7989922 | 0.81 | SIRT2 (0.48) | PARP1CHEK2PIN1CFTRPRKAB2 | |
| SCHEMBL7978052 | 0.80 | PARP1 (0.46) | PARP1MEN1KMT2AGAAMAPT | |
| SCHEMBL7991959 | 0.79 | SMN1; SMN2 (0.44) | PARP1PIN1AKR1C3PRKAB2PRKAG1 | |
| SCHEMBL7989265 | 0.79 | SIRT2 (0.47) | CHEK2PIN1SIRT2SIRT1MEN1 | |
| SCHEMBL7991843 | 0.79 | AURKA (0.45) | PARP1CHEK2AKR1C3PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288061-B1 | INTERLEUKIN INHIBITORS; ASTHMA, BRONCHODILATOR AGENTS, ANTIALLERGENS | WELFIDE CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |