Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19309488 | 0.86 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1HTR2CF2PRSS1 | |
| SCHEMBL7982578 | 0.85 | TMPRSS2 (0.64) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7419632 | 0.82 | PRSS1 (0.64) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7986829 | 0.81 | PRMT1 (0.65) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7427347 | 0.81 | PRMT1 (0.65) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7989663 | 0.81 | PRMT1 (0.65) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7986010 | 0.81 | PRSS1 (0.63) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7972474 | 0.81 | TMPRSS2 (0.57) | SMN1; SMN2HTR2CF2ITGB3ITGA2B | |
| SCHEMBL7972008 | 0.80 | F10 (0.62) | SMN1; SMN2F2ITGB3ITGA2BTMPRSS2 | |
| SCHEMBL7986022 | 0.77 | F10 (0.45) | SMN1; SMN2ITGB3ITGA2BTMPRSS2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221914-B1 | ANTIINFLAMMATORY AGENTS | ARRAY BIOPHARMA INC. | 2001-04-24 | — | — | US | disclosed |