Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.43 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858881 | 0.86 | TSHR (0.46) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL19624534 | 0.86 | ALDH1A1 (0.50) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6410232 | 0.86 | PTGDR2 (0.63) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6964474 | 0.83 | SMN1; SMN2 (0.58) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL6044488 | 0.82 | KDM4E (0.53) | LMNAKMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3988013 | 0.82 | LMNA (0.56) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL15270920 | 0.80 | KMT2A (0.55) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL20869137 | 0.79 | CCR5 (0.58) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL18512351 | 0.79 | ALDH1A1 (0.52) | LMNAKMT2ARAB9ASMN1; SMN2HPGD | |
| SCHEMBL16294248 | 0.78 | USP28 (0.69) | LMNAKMT2ARAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |