Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.51 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.49 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7990173 | 1.00 | DRD2 (0.51) | DRD2SLC6A4HTR2ADRD4CHRM4 | |
| Maleic Acid SCHEMBL9038026 | 0.82 | DRD2 (0.50) | DRD2SLC6A4HTR2ADRD4HTR1A | |
| Fumaric Acid SCHEMBL9038029 | 0.82 | DRD2 (0.50) | DRD2SLC6A4HTR2ADRD4HTR1A | |
| SCHEMBL9037333 | 0.74 | DRD2 (0.57) | DRD2SLC6A4HTR2ADRD4HTR1A | |
| Hydrochloric Acid SCHEMBL7989995 | 0.73 | DRD2 (0.56) | DRD2SLC6A4HTR2ADRD4HTR1A | |
| SCHEMBL7993011 | 0.73 | DRD2 (0.58) | DRD2SLC6A4HTR2ADRD4CHRM4 | |
| SCHEMBL3122425 | 0.72 | DRD2 (0.66) | DRD2SLC6A4HTR2ACHRM4HTR1A | |
| Maleic Acid SCHEMBL8671967 | 0.72 | DRD2 (0.46) | DRD2SLC6A4DRD4CHRM4TAAR1 | |
| SCHEMBL3122433 | 0.71 | SLC6A4 (0.70) | DRD2SLC6A4CHRM4HTR1A | |
| SCHEMBL6707211 | 0.71 | DRD2 (0.63) | DRD2SLC6A4HTR2AHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284775-B1 | PSYCHOLOGICAL DISORDERS | AVENTIS PHARMACEUTICALS INC. | 2001-09-04 | — | — | US | disclosed |
| EP-0699675-A2 | 3-(4-(1-Substituted-4-piperazinyl)butyl)-4-thiazolidinone and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-03-06 | — | — | EP | disclosed |