Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 4/20 | 0.32 |
| ▸ | CTSL | P07711 | 3/20 | 0.32 |
| ▸ | CTSS | P25774 | 3/20 | 0.32 |
| ▸ | CTSK | P43235 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.31 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990402 | 1.00 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7986213 | 0.85 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPT | |
| SCHEMBL7987070 | 0.82 | PLA2G2C (0.34) | ALDH1A1 | |
| SCHEMBL7987314 | 0.82 | MME (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7975796 | 0.80 | ALDH1A1 (0.32) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL7986623 | 0.77 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7975696 | 0.77 | SLC7A5 (0.39) | ALDH1A1LMNAMAPT | |
| SCHEMBL7975699 | 0.77 | SLC7A5 (0.39) | ALDH1A1LMNAMAPT | |
| SCHEMBL7993920 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ACTSLMAPT | |
| SCHEMBL7993921 | 0.76 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ACTSLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040198-A2 | MACROCYCLIC HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS ANTIMICROBIAL AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-06-07 | — | — | WO | disclosed |