Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.54 |
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | FAAH | O00519 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 4/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7991573 | 1.00 | DRD4 (0.57) | DRD4FAAHDRD2DRD3HTR7 | |
| SCHEMBL7498974 | 0.89 | DRD4 (0.72) | DRD4FAAHDRD2DRD3HTR7 | |
| SCHEMBL1540225 | 0.82 | DRD4 (0.54) | DRD4FAAHDRD2DRD3HTR1A | |
| Maleic Acid SCHEMBL7977396 | 0.82 | DRD4 (0.83) | DRD4DRD2DRD3HTR7HTR1A | |
| Fumaric Acid SCHEMBL7977401 | 0.82 | DRD4 (0.83) | DRD4DRD2DRD3HTR7HTR1A | |
| SCHEMBL15937714 | 0.82 | SIGMAR1 (0.66) | DRD4DRD2DRD3HTR7HTR1A | |
| SCHEMBL15937926 | 0.80 | MAPT (0.61) | DRD4DRD2DRD3HTR7HTR1A | |
| SCHEMBL15937826 | 0.80 | DRD4 (0.78) | DRD4DRD2DRD3HTR7 | |
| SCHEMBL15937936 | 0.80 | DRD4 (0.67) | DRD4DRD2DRD3HTR1A | |
| SCHEMBL1540224 | 0.80 | DRD4 (0.54) | DRD4FAAHDRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |